THE OPTIMIZATION OF PROLONGED RELEASE - revista farmacia延长释放药学杂志的优化.docVIP

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THE OPTIMIZATION OF PROLONGED RELEASE - revista farmacia延长释放药学杂志的优化.doc

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THE OPTIMIZATION OF PROLONGED RELEASE OF MATRIX TABLETS WITH FELODIPINE R.I. IOVANOV*, I. TOMUTA, S.E. LEUCUTA Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu Hatieganu” University, 400023, Cluj-Napoca, ROMANIA *corresponding author: iovanovraresiuliu@ Abstract The objective of this work was to prepare and optimize some prolonged release matrix type tablets with felodipine based on Kollidon SR, in order to obtain similar release profiles with the original product. In this regard a full experimental design with 2 factors and 3 variables was used in order to observe the influence of the formulation variables on the characteristics of the tablets. The studied variables where: percent of Kollidon SR in the tablet and diferent fillers. The tablets where characterized from the point of view of the pharmaceutical properties (mechanical strength, friability and in vitro dissolution behavior). The results showed that the percent of Kollidon SR in the tablets has the biggest effect on the release of felodipine. The optimum formula generated from the experimental data was similar with the original product. Rezumat Obiectivul acestei lucr?ri a fost ob?inerea ?i optimizarea unor preparate farmaceutice solide cu cedare prelungit? de tip matri?a pe baz? de Kollidon SR cu felodipina pentru a ob?ine o formulare similar? ca profil de dizolvare cu preparatul original. ?n acest scop a fost dezvoltat un plan experimental complet cu 2 factori ?i trei variabile. Factorii studia?i au fost procentul de Kollidon SR din comprimate ?i excipien?ii diluan?i folosi?i. Comprimatele au fost caracterizate din punct de vedere al rezistentei mecanice, friabilit??ii ?i a dizolv?rii in vitro. Rezultatele arat? c? procentul de Kollidon SR din formulare are cea mai mare influen?? asupra vitezei de cedare a felodipinei. Formularea optimizat? preparat? s-a dovedit a fi similar? cu cea a produsului original. felodipine optimization prolonged release I