ALLHAT.课件 - Hypertension Online.pptVIP

下载本文档

3
0
约2.12万字
约 17页
2018-03-14 发布于天津
举报
版权申诉

ALLHAT.课件 - Hypertension Online.ppt

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT study overview Double-blind, randomized trial to determine whether the occurrence of fatal CHD or nonfatal MI is lower for high-risk hypertensive patients treated with newer agents (amlodipine, lisinopril, or doxazosin) compared with a diuretic (chlorthalidone) Cohort 42,418 patients (?55 years old) from 623 sites in North America Stage 1 or 2 hypertension 1 additional risk factor for CHD Comparisons between chlorthalidone and amlodipine and chlorthalidone and lisinopril have been reported together, excluding the doxazosin arm (n=9,062), which was terminated early ALLHAT Research Group. JAMA. 2002;288:2981-2997. CHD=coronary heart disease; MI=myocardial infarction ALLHAT Study Design n=13,854 2,235 (16.1%) stopped drug Chlorthalidone n=15,255 Amlodipine n=9,048 Randomized n=42,418 n=15,255 339 (2.2%) lost to follow-up80 (0.5%) refused follow-up n=9,048 200 (2.2%) lost to follow-up58 (0.6%) refused follow-up n=6,2101,873 (30.2%) stopped drug n=9,054 218 (2.4%) lost to follow-up58 (0.6%) refused follow-up n=8,215 1,357 (16.5%) stopped drug n=3,7691,052 (27.9%) stopped drug YEAR 1 n=8,158 1,842 (22.6%) stopped drug n=3,605 1,399 (38.8%) stopped drug Lisinopril n=9,054 YEAR 5 ALLHAT Research Group. JAMA. 2002;288:2981-2997. Intent-to-Treat Analysis Doxazosin n=9,062 Discontinued early at 3.3 yrs ALLHAT Endpoints Primary endpoint Composite of fatal coronary heart disease (CHD) or nonfatal myocardial infarction (MI) Other predefined endpoints all-cause mortality stroke combined CHD – nonfatal MI, CHD death, coronary revascularization, hospitalized angina combined cardiovascular disease – combined CHD, stroke, lower extremity revascularization, treated angina, fatal/ hospitalized/treated congestive heart failure, hospitalized or outpatient peripheral arterial disease other – renal ALLHAT Research Group. JAMA. 2002;288:2981-2997. Chlorthalidone n=15,255 Amlodipine n=9,