acute liver failure.课件.pptVIP

Acute Liver Failure;Foie gras?(pronounced?/fwɑ??ɡrɑ?/?in English;?French?for fat liver) is a?food product?made of the?liver?of a?duck?or?goose?that has been specially fattened.;Metabolic Carb metabolism Protein and lipoprotein metabolism Fatty acid metabolism Biotransformation of drugs Storage Glycogen Vitamins A, D, E, and K Iron and copper;Immunological function s Synthesis of immunoglobulins Phagocytosis by Kupffer cells Filtration of bacteria Degradation of endotoxins Excretion of bilirubin and urea formation Haematological functions Blood reservoir Haematopoiesis in the foetus;ALF;Definition and Classifications;Definition and Classifications;Workup;Workup;Pathophysiology;Pathophysiology;Clinical Features;Scale Of Hepatic Encephalopathy;Clinical Features;Clinical Features;Clinical Features;Clinical Features;Monitoring;Prognosis;KCH Criteria;Positive predictive value for ICU death without transplantation of 0.98 Negative predictive value of 0.82;Treatment;Treatment;General Management;General Management;General Management;Management of Complications;Encephalopathy;Infection prophylaxis and surveillance;Infection prophylaxis and surveillance;Sedation and analgesia;Correction of bleeding diathesis;Correction of bleeding diathesis;Correction of bleeding diathesis;Nutrition;Seizure Prophylaxis and Surveillance;CVS Dysfunction;Mx. of Cerebral Oedema and Intracranial Hypertension;Raised ICP;Raised ICP;Mechanical Ventilation;Mechanical Ventilation;CRRT;CRRT;Orthotopic liver transplant is the definitive treatment for patients who meet the criteria or·tho·top·ic?(?rth-tpk)adj.In the normal or usual position 1 yr. and 5 yr . survival of patients undergoing OLT for ALF is about 20% lower than elective cases for cirrhotic patients Auxiliary liver transplantation is and alternative;Absolute contraindications Overwhelming sepsis Refractory hypotension AIDS Uncontrolled raised ICP with likely permanent damange;MARS: molecular absorption and recirculation system Adaptation of hae