痛痹方对佐剂性关节炎大鼠踝关节组织病理改变的影响.PDFVIP

·44· Chinese Journal of Information on TCM Apr.2007 Vol.14 No.4 痛痹方对佐剂性关节炎大鼠踝关节组织 病理改变的影响 何晓瑾,夏卫军,金 实 (南京中医药大学,江苏 南京 210029) 摘要：目的 观察痛痹方对佐剂性关节炎大鼠踝关节组织病理改变的影响。方法 将大鼠随机分成正常组、模 型组、痛痹方高剂量组、痛痹方中剂量组、痛痹方低剂量组、雷公藤多甙片组,每组 10 只,除正常组外,其余各组用 弗氏完全佐剂诱导关节炎发生,观察各组大鼠踝关节滑膜、关节腔、周围软组织炎症反应等组织病理改变情况,进行 综合病变评分。结果 与模型组相比,痛痹方高、中剂量组和雷公藤多甙片组的大鼠踝关节组织病理改变均有明显减 轻(P 0.05或 P 0.01)。结论 痛痹方有抑制类风湿性关节炎组织病理改变的作用。 关键词：痛痹方；佐剂性关节炎；病理改变 中图分类号：R289.11 文献标识码：A 文章编号：1005-5304(2007)04-0044-03 Effect of Tongbi Prescription on the Pathomorphological Changes of Ankles in Adjuvant Arthritis Rats HE Xiao-jin, XIA Wei-jun, JIN Shi (Nanjing University of TCM, Nanjing 210029, China) Abstract ：Objective To observe the effect of Tongbi Prescription on pathomorphological changes of ankles in adjuvant arthritis rats. Methods Rats were randomly divided into six groups: normal control group, model control group, three Tongbi Prescription treated group (respectively with high-, mid- and low-dosages), Tripterygium glycosides treated group (each n =10). Except for the rats of normal control group, the others were injected with Freund’s complete adjuvant. The pathomorphological changes of ankles of each group were measured. Results The pathomorphological changes of high- and mid- dosages Tongbi Prescription treated group and Tripterygium glycosides treated group were lightened than those of model control group obviously (P 0.05 or P 0.01). Conclusion Tongbi Prescription can alleviate the changes of the pathomorphology affected with rheumatoid arthritis. Key words：Tongbi Prescription ；adjuvant arthritis；pathomorphological changes 类