坩埚对一水葡萄糖失水的影响InfluenceofthePanonDehydration.PDF

坩埚对一水葡萄糖失水的影响 Influence of the Pan on Dehydration, Glucose Monohydrate 试样 α-D-一水葡萄糖 Sample α-D-Glucose monohydrate 应用 非活性成分，药片和胶囊的填料 Application Inactive ingredient, filler for tablets and capsules 条件 测试仪器：DSC和TGA Conditions Measuring cell: DSC and TGA DSC坩埚：40μl铝坩埚，密封或盖钻孔。 Pan DSC: Al 40μl, hermetically sealed or with pierced lid. TGA坩埚：100μl铝坩埚，盖钻孔。 Pan TGA: Al 100μl, with pierced lid. 试样制备：原样品 Sample preparation: As received DSC 测试：以20K/min由30°C升温至250°C。 DSC Measurement: Heating from 30°C to 250°C at 20 K/min. TGA 测试：以20K/min 由30°C升温至300°C。 TGA Measurement: Heating from 30°C to 300°C at 20 K/min. 气氛：氮气，DSC ：50 ml/min ，TGA ：80 ml/min Atmosphere: Nitrogen, DSC: 50 ml/min ，TGA: 80 ml/min 图3.7 α-D-一水葡萄糖在钻孔盖坩埚(上)和密封坩埚(下) 中测试得到的DSC 曲线 Figure 3.7 DSC curves of α- D-Glucose monohydrate measured at pan with pierced lid (above) and sealed pan (below) 图3.7 所示α-D-一水葡萄糖两条DSC 曲线的比较，表明了试样在密封坩埚或在盖钻孔 解释 的坩埚中测试时产生的变化。如果用盖钻孔的坩埚，结晶水可以逃逸，这从测试开始 Interpretation 时DSC 曲线的移动和宽泛的蒸发峰可明显观察到。同时，出现向β-D-无水葡萄糖的转 变，它的熔点约为158°C。200°C 以上，葡萄糖开始熔化变焦。 A comparison of the two DSC curves of α-D-Glucose monohydrate in Fig. 3.7 shows the changes that arise when the sample is measured in a sealed pan or in a pan with a pierced lid. In a hermetically sealed pan the sharp melting peak of the monohydrate can be observed. If a pan with a pierced lid is used, the w