i【医学论文】l-1β、il-6、il-10变化规律与温病营分证病机关系研究.docVIP

??????????????? 作 者：肖碧跃,赵国荣,艾碧琛,曾序求【摘要】? 目的 观察营分证白细胞介素(il)-1β、il-6、il-10变化规律,探讨温病营分证的病机实质。方法 将104例患者按不同病种分为急性白血病、非急性白血病。根据中医辨证,急性白血病分为卫分证组(白卫组)10例,气分证组(白气组)12例,营分证组(白营组)20例；非急性白血病分为卫分证组(非白卫组)20例,气分证组(非白气组)24例,营分证组(非白营组)18例。另选择体检健康者15例为健康对照组。观察不同病种营分证与卫分证、气分证患者il-1β、il-6、il-10变化规律。结果 在营分证阶段,急性白血病、非急性白血病il-1β、il-6的表达显著升高,而il-10显著下降,与健康对照组比较差异均有统计学意义(p＜0.01)。不同病种间il-1β无差异(p＞0.05),而il-6与il-10差异有统计学意义(p＜0.01)。结论 il-1β、il-6、il-10的变化规律可为营分证病机实质提供客观指标。 【关键词】? 温病；急性白血病；白细胞介素-1β；白细胞介素-6；白细胞介素-10 ??? abstract：objective to observe the change regularity of il-1β, il-6, il-10 and explore the mechanism of yingfen syndrome (ys) in epidemic febrile diseases. methods one hundred and four cases were divided into acute leukemia (al) group and non-acute leukemia (nal) group according to different diseases. according to syndrome differentiation of tcm, al group was classified to 10 cases for weifen syndrome (ws), 12 cases for qifen syndrome (qs), and 20 cases for ys. nal group was classified to 20 cases for ws, 24 cases for qs and 18 cases for ys. fifteen healthy persons were selected for comparison. the levels of il-1β, il-6 and il-10 in ys, ws and qs of various diseases were observed. results in ys period, il-1β and il-6 increased continuously, while il-10 decreased markedly, compared with healthy people (p＜0.01). there was no significant difference in il-1β (p＞0.05), while on difference in il-6, il-10 between different diseases (p＜0.01). conclusion the change regularity of il-1β, il-6 and il-10 can provide objective parameters of mechanism substance of ys.??? 　　key words：epidemic febrile disease；acute leukemia；interleukin-1β；interleukin-6；interleukin-10???? 在卫气营血辨证中,“卫之后方言气,营之后方言血”。病情由卫到气传营,是病邪由浅入深,病情由轻转重,病性由实转虚,病理由器官功能性障碍到实质性损伤的过程。其中营分证是由气传营,病邪由浅入深,病情由轻转重,病性由实到虚,病理由器官功能性障碍到实质性损伤的阶段。热入营分,也是病势进退的枢机时刻,进则深入血分,退则犹可转出气分,邪去正复而愈。如果能充分认识营分证的本质,在营分证时及时采取措施,则有利于截断和防止病变的进一步发展,从而达到治疗的目的,减少死亡的发生。近年来,在中西医结合实践中,随着对细胞因子的研究不断深入,人们越来越清楚地认识到内源性炎症介质在感染引起的炎症反应中起着重要的作用,同时认为炎性介质的释放是呈连锁反应进行的,反应过程通常分几个阶段进