抗生素的选择（英文）ANTIBIOTICS ASHWINIPPT.pptVIP

ANTIBIOTICS;The selection of antibiotic therapy for an infection requires a knowledge of: 1The infecting organism, including the pathogen most likely to be present in given clinical or geographical circumstances 2The local patterns of antimicrobial resistance in common pathogens 3 An understanding of the pharmacokinetics of the antimicrobials selected 4 The physiology of the patient, metabolic upset, renal or hepatic dysfunction, age and available routes of administration. The clinical history should determine the systems of the body most likely to be involved in disease. Figure 6.3 (p. 133) shows common pathogens found in different systems. ;ENDOGENOUS INFECTIONS-RESERVOIRS OF INFECTIONS IN ADULTS;Common Infecting Organisms.;Empirical treatment Prior to Identification of Organism;C.Determining the Antimicrobial Susceptibility of the Organism;E. Patient Factors;Route of Administration Determination of Rational Dosing 1 Concentration dependent killing 2. Post antibiotic effect;SITES OF MICROBIAL ACTION;Chemotherapeutic Spectra;DRUG RESISTENCE;PROPHYLACTIC ANTIBIOTICS;COMPLICATIONS OPF ANTIBIOTIC THERAPY;Inhibitors of Cell Wall Synthesis;PENICILLIN;PENICILLIN G;Extended Penicillins;Anti Staphylococcal Penicillins;ADVERSE EFFECTS OF PENICILLINS; Stability of penicillins to acid penicillinases;CEPHALOSPORINS;OTHER BETA LACTAM ANTIBIOTICS-CARBAPENEMS MONOBACTAMS;OTHER CELL WALL INHIBITORS- VANCOMYCIN