药物化学教学课件.pptVIP

Medicinal Chemistry药物化学 Lecturer： Huang Honglin 主讲教师： 黄洪林 B.S. Jiangxi College of TCM(1978~1982) M.S. Beijing China-Japan Friendship Institute of Medical Science(1987~1990) Email: huang999@263.net 药 物 化 学 Medicinal Chemistry 第一章： 绪 论 Introduction to Medicinal Chemistry 绪 论 药物定义-化学药物 药物，无论是天然药物(植物药、抗生素、生化药物)、合成药物和基因工程药物，就其化学本质而言都是一些化学元素组成的化学品。然而药物不仅仅是一般的化学品，它们是人类用来预防、治疗、诊断疾病，或为了调节人体功能、提高生活质量、保持身体健康的特殊化学品。 药物化学，强调研究药物的化学特性。 国外对药物的定义 Physicians use special chemical compounds to diagnose, prevent, or treat certain kinds of diseases. These compounds are called drugs. A more scientific name for them is pharmaceuticals. 中药及草药不列入药物范畴 Dietary Supplements 食物增补剂 Alternative Medicine 替代医学 药物化学的定义 本教材对药物化学的定义： “药物化学”是一门发现与发明新药、合成化学药物、阐明药物化学性质、研究药物分子与机体细胞(生物大分子)之间相互作用规律的综合性学科，是药学领域中重要的带头学科。 (第四版、第五版) [ 必威体育精装版教材为第五版] 药物化学定义的变化 研究化学药物的化学结构，理化性质，化学制备，体内代谢，化学结构与药效相互关系，药物作用的化学机理，以及寻找新药的途径和方法的一门学科。(1-3版) 药物合成成为专业及专门课程，属于化学制药专业的重点课程。 理化性质用于鉴别及含量测定归属于药物分析课程。 Definition of Medicinal Chemistry Medicinal chemistry is an interdisciplinary subject . This course will cover the field of medicinal chemistry especially as it relates to the mechanism and techniques of drug design and drug action. Topics to be covered include methods of drug discovery such as rational drug design through structure activity relationships and molecular modeling. 国外药物化学更看重药物作用机理及新药发现方法 药物化学工作是药物发现的支柱 The medicinal chemist is a pillar within the health care system since the majority drugs come from their minds and their flasks. What is medicinal chemistry Simply, medicinal chemistry is the application of organic chemistry to the discovery, design and synthesis of new drugs. The medicinal chemist can be viewed as the originator of drugs that subsequently reach the clinic. （药物发明人） How a Medicinal Chemist Do Medicinal chemistry is an interdisciplinary science. 交叉学科 Its successful application to new drug discovery and development involves knowledge of organic chemistry, biology, physiolog