铝碳酸镁联合奥美拉唑治疗幽门螺杆菌感染活动性溃疡的疗效观察.docVIP

精品论文 参考文献 铝碳酸镁联合奥美拉唑治疗幽门螺杆菌感染活动性溃疡的疗效观察 张书荷 　　（天津公安消防总队医院 300074） 　　【摘要】 目的 评估铝碳酸镁联用奥美拉唑治疗活动性胃溃疡的临床疗效。方法 将120例经胃镜证实伴幽门螺杆菌感染的活动性胃溃疡患者，随机分为观察组(61例)和对照组(59例)。治疗第1周，对照组患者给予幽门螺杆菌根除三联疗法，奥美拉唑（20mg，2次/天）+阿莫西林（1000mg，2次 /天）+克拉霉素（500mg， 2次/天），第2～6周给予奥美拉唑20mg，3次 /天，第7～8周停药。观察组在对照组的基础上给予铝碳酸镁咀嚼片（500mg /片，3次/天，1片 /次，）治疗，连续治疗8周。结果 服药1天后，观察组患者上腹痛缓解的发生率显著优于对照组(Plt;0.05)。治疗8周后，两组内镜下溃疡愈合总有效率差异无统计学意义(Pgt;0.05)，但痊愈率观察组显著高于对照组(Plt;0.05)。观察组1年溃疡复发率显著低于对照组。结论 联合应用在质子泵抑制剂奥美拉唑和胃黏膜保护剂铝碳酸镁治疗活动性胃溃疡，能更快缓解临床症状，提高愈合质量，降低复发率。 　　【关键词】胃溃疡 幽门螺杆菌感染 铝碳酸镁 奥美拉唑 　　【中图分类号】R969.4 【文献标识码】A 【文章编号】1672-5085（2014）22-0043-02 　　Evaluation of hydrotalcite combined with omeprazole in treatment of gastric ulcer 　　【Abstract】 0bjective To evaluate the clinical effect after the treatment of Hydrotalcite combined with omeprazole in the patients with active gastric ulcer．Methods One hundred twenty patients with active gastric ulcer and Helicobacter pylori(H．pylori)infection were randomized into the observation group(n=61)and control group(n=59)．In the 1st week，control group received H．pylori eradication regimen, patients received omeprazole 20 mg /Amoxicillin 1000mg / Clarithromycin 500mg twice a day. In the 2nd to 6th week，the control group received omeprazole 20 mg 3 times a day . In the 7th to 8th week, the control group didnrsquo;t received drugs. On the basis of control group, the observation group received the Hydrotalcite Tablets(500mg, 3 times a day) for 8 weeks. Results After 1 days of treatment, upper abdominal pain remission rate in the observation group was was significantly better than the control group (Plt;0.05). After 8 weeks, there was no significant difference between the two groups on the ulcer healing rate evaluated by endoscopy(Pgt;0.05). The recovery rate was significantly higher in the observation group(Plt;0.05). 1 years recurrence rate of the observation group was significantly lower than the control group(Plt;0.05). Conclusion In acti