ⅰb2、ⅱa2期宫颈癌术前新辅助化疗与腔内放疗对比研究.docVIP

ⅠB2、ⅡA2期宫颈癌术前新辅助化疗与腔内放疗对比研究 　　【摘要】 目的：?Ρ确治鍪跚靶赂ㄖ?化疗与腔内放疗在ⅠB2、ⅡA2期宫颈癌治疗中的应用价值。方法：选取2009年2月-2013年12月本院收治的ⅠB2、ⅡA2期宫颈癌患者60例，将其随机分为两组，每组30例。两组均给予广泛性子宫切除术与盆腔淋巴清扫术，其中对照组术前采用腔内放疗，观察组予以术前新辅助化疗。比较两组肿瘤缩小情况、手术情况、复发率、生存率及不良反应发生率。结果：观察组肿瘤缩小总有效率为83.33%，与对照组的60.00%相比明显增加，差异有统计学意义（P0.05）。结论：术前新辅助化疗治疗ⅠB2、ⅡA2期宫颈癌较腔内放疗更有助于促进肿瘤缩小，改善近期疗效，提高患者生存率，应用价值更为明显。 　　【关键词】 宫颈癌； 新辅助化疗； 腔内放疗 　　Comparative Study on Preoperative Neoadjuvant Chemotherapy and Intracavitary Radiotherapy inⅠB2，ⅡA2 Stage Cervical Cancer/XU Shao-yu，WU Su-fang，JIANG Shao-ru，et al.//Medical Innovation of China，2017，14（14）：043-046 　　【Abstract】 Objective：To compare and analyze the application value of preoperative neoadjuvant chemotherapy and intracavitary radiotherapy in treatment of ⅠB2，ⅡA2 stage cervical cancer.Method：From February 2009 to December 2013，60 patients with ⅠB2，ⅡA2 stage cervical cancer admitted into our hospital were selected and divided into control group and observation group according to the random number table method，30 cases in each group.Both two groups were given radical hysterectomy and pelvic lymphadenectomy，the control group took preoperative intracavitary radiotherapy and the observation group took preoperative neoadjuvant chemotherapy. The tumor regression situation，surgical situation，recurrence rate，survival rate and incidence of adverse reactions of two groups were compared.Result：The total effective rate of tumor regression of the observation group（83.33%） was higher than that of the control group（60.00%），the difference was statistic significant（P0.05）.Conclusion：Preoperative neoadjuvant chemotherapy treating for ⅠB2，ⅡA2 stage cervical cancer can facilitate tumor regression，improve the short-term efficacy，increase the survival rate，which has application value. 　　【Key words】 Cervical cancer； Neoadjuvant chemotherapy； Intracavitary radiotherapy 　　First-author’s address： People’s Hospital of Jieyang，Jieyang 522000，China 　　doi：10.3969/j.issn.1674-4985.2017.14.012 　　早期宫颈癌患者单纯应用手术治疗可取得相对良好的效果，