部分缺血性脑卒中患者颈动脉斑块稳定性与血清CRP相关性分析.docVIP

精品论文 参考文献 部分缺血性脑卒中患者颈动脉斑块稳定性与血清CRP相关性分析 许育伟１,２　何文贞３通讯作者 　　１．广东省汕头大学医学　广东　汕头　５１５０６３;２．广东省潮州市人民医院　广东　潮州　５２１０００;３．广东省汕头大学第一附属医院　广东　汕头　５１５０４１ 　　【摘要】　目的　探讨部分缺血性脑卒中患者颈动脉斑块稳定性与血清CRP相关性.方法　随机选取６０名从２０１３年１月至２０１５年１月在本院神经内科收治的缺血性卒中患者,通过彩色多普勒检测,按颈动脉斑块稳定性分为观察组(伴易损斑块)、对照组(伴稳定斑块或不伴斑块[１－３]),动态观察斑块情况、血清CRP[４],比较分析部分缺血性脑卒中患者颈动脉斑块稳定性相关因素.结果　易损斑块与血清CRP的关系:１d、７d、１５d观察组CRP的水平明显高于对照组(P＜０．０１、P＜０．０１、P＜０．０５),３０d、９０d观察组CRP比较无显著性差异(P＞０．０５),观察病例血清CRP在１５天内与易损斑块相关.经治疗后部分易损斑块可转化为稳定斑块,如表２．２,符合血清CRP在急性期(１５天)与易损斑块相关,经治疗后,易损斑块可趋向稳定,转化为稳定斑块,与CRP无相关性.结论　部分缺血性脑卒中患者颈动脉稳定性与CRP相关. 【关键词】　缺血性脑卒中;　血清CRP;　颈动脉粥样硬化;　易损斑块correlationstudyofcarotidarteryplaquestabilityandserumCRPinpatientswithischemicstrokeYuweiXu１,２　Wenzhen He３　(１．MedicalCollegeofShantouUniversity,Shantou,Guangdong ５１５０６３;２．ChaozhouPeoplersquo;s HospitalofGuangdong, Chaozhou,Guangdong ５２１０００;３．Hospitalof MedicalCollegeofShantouUniversity,Shantou,Guangdong ５１５０４１)【Abstract】　Objective:toexplorethecorrelationbetweencarotidarteryplaquestabilityandserumCRPinpatientswithischemicstrokeMethods:６０patientswithischemicstrokewererandomlyselectedfromJanuary２０１３toJanuary２０１５inourneurologicalinpatientdepartment．UsingcolordopplertodetectthestabiliＧtyofcarotidplaques,thepatients weredividedintoobservationgroup (withvulnerableplaques)andthecontrolgroup (withstableplaquesor withoutplaques[１－３]),andthenthechangingplaquesstabilityandserumCRP[４]wererecordedandanalyzed．Results:thecorrelationbetweenvulnerableplaquesandserＧum CRP:on１d,７d,１５d,theCRPlevelofobservationgroupwasobviouslyhigherthanthatofcontrolgroup(P＜０．０１、P＜０．０１、P＜０．０５),on３０dand９０dTherewasnosignificantdifferencebetweentwogroups(P＞０．０５)．TheserumCRPisassociatedwithvulnerableplaquesinthefirst１５days．Aftertreatmentwhenthevulnerableplaqueswereconvertedintostableplaquesandthere＇snocorrelationwithCRPanymore．Conclusion:thecarotidarteryplaquestabilityisassociatedwiths【eKreuymwoCrRdsP】inpatientswithischemicstroke． 　Ischemicstroke;　SerumCRP;Carotidatheroscleroticvulnerableplaques 【中图分类号】R７４３ 【文献标识码】B 　　【文章编号】１００８－６３１５(２０１５