部分肥大细胞相关抗体及分子在自身免疫性肝病患者中的表达.docVIP

精品论文 参考文献 部分肥大细胞相关抗体及分子在自身免疫性肝病患者中的表达 赵凯（商丘市第一人民医院检验科 河南商丘 476100） 　　【摘要】目的: 探究部分肥大细胞相关抗体和分子在自身免疫性肝病患者中的表达水平。方法： 选择自身免疫性肝病患者30 例为观察组，将选择同期收治的病毒性肝炎等其他肝脏疾病患者30 例为对照组。采用酶联免疫吸附测定法检测血清标本肥大细胞相关抗体和分子情况。 　　结果：观察组抗AMA-M2、抗gp210 和抗SP100 阳性率高于对照组，而抗LC-1、LKM-1 以及抗SLA 阳性率低于对照组，除抗SLA 外，差异显著（P ＜ 0.05）。观察组Fcepsilon;R Ialpha; 低于对照组，IMG 水平高于对照组，差异显著（P ＜ 0.05）。结论：自身免疫性肝病的Fcepsilon;R Ialpha; 相比于其他肝病患者显著降低。肥大细胞相关的抗IgE、Fcepsilon;R Ialpha; 以及抗Fcepsilon;R I 水平均会参与到肝脏疾病的产生和发生过程中，对机体造成损伤。 　　【关键词】肥大细胞；抗体；分子；自身免疫性肝病【中图分类号】 R2 【文献标号】 A 【文章编号】 2095-9753（2016）3-0042-02Part of the mast cells related antibodies and molecular expression in patients with autoimmune liver diseaseZhao Kai (shangqiu first peoples hospital clinical laboratory Henan shangqiu, 476100)[abstract] objective: to explore the part of the mast cells related antibodies and molecular expression level in patients withautoimmune liver disease. Methods: 30 patients with autoimmune liver disease as the observation group, will choose the same other liverdiseases such as viral hepatitis patients treated 30 cases as control group. Using enzyme-linked immunosorbent assay to detect serumspecimens of mast cells related antibodies and molecules. Results: the observation group of AMA - M2, gp210 resistance and resistanceto SP100 positive rate is higher than the control group, and the resistance against LC - 1, LKM - 1 and SLA positive rate is lowerthan the control group, in addition to the resistance to the SLA, significant difference (P lt; 0.05). Observation group Fc epsilonR I alpha is lower than the control group, IMG level higher than the control group, significant difference (P lt; 0.05). Conclusion:autoimmune liver diseases Fc epsilon R I alpha compared to other liver disease significantly reduced. Mast cells related to anti IgE,Fc epsilon R I alpha and against Fc epsilon R I level will be involved in the production and the process of liver disease, cause damageto the body.[key words] : mast cells; Antibody; Molecules; Autoimmune liver