Respiratory failure 病理生理学双语课件.pdf

Respiratory failure (RF) Department of Pathophysiology, Guangxi Medical University Review Ventilation + gas exchange External respiration External respiration Tissue cell Tissue cell RESPIRATION RESPIRATION transportation transportation Internal respriation Internal respriation Process of external respiration Chapter outline Concept and classification Etiology and Pathogenesis Metabolic and functional alternations Principles of treatment Concept The inability of the respiratory system to adequately oxygenate the blood with or without a concurrent alteration in carbon dioxide increase. A syndrome rather than a disease Concept and classification External respiratory dysfunction  Hypoxemia with or without hypercapnia  PaO 60 mmH with or without PaCO 50 2 2 mmH Hypoxemia Hypercapnia group I - hypoxemic RF group II Hypercapnic RF Dissociation curve of oxyhemoglobin Dissociation curve of oxyhemoglobin 100 80 SO SO2 2 % 60 % 40 20 20 40 60 80 100 PaO (mmHg) PaO (mmHg) 2 2 Classification Group I vs Group II Ventilatory RF vs Exchanging RF Central