酶法转化制备人参皂苷单体的研究进展-天津中草药杂志社.PDFVIP

·3356 · 中草药 Chinese Traditional and Herbal Drugs 第45 卷 第22 期 2014 年11 月 酶法转化制备人参皂苷单体的研究进展 * * 姬 庆，郜玉钢 ，赵 岩，何忠梅，臧 埔，张连学 吉林农业大学中药材学院，吉林 长春 130118 摘 要：人参皂苷具有抗肿瘤、抗病毒、延缓衰老、增强免疫等多种药理活性，但不同皂苷单体在药材及其提取物中量不同， 其药理活性亦有差异，量低而药理活性强的皂苷单体需大量制备，以满足医疗和科研需要。如何定向提高人参皂苷单体的量， 酶法制备是解决该问题的关键技术，且利用该法有效定向获得人参皂苷单体进行了大量研究。就酶法转化制备人参皂苷单体 进行综述，为人参皂苷单体的进一步开发利用提供理论依据和参考。 关键词：酶法；人参皂苷；生物转化；人参皂苷Rg1；人参皂苷Rg3 中图分类号：R282.1 文献标志码：A 文章编号：0253 - 2670(2014)22 - 3356 - 05 DOI: 10.7501/j.issn.0253-2670.2014.22.026 Research progress on enzymatic conversion for preparing individual ginsenosides JI Qing, GAO Yu-gang, ZHAO Yan, HE Zhong-mei, ZANG Pu, ZHANG Lian-xue College of Traditional Chinese Medicinal Materials, Jilin Agriculture University, Changchun 130118, China Abstract: Ginsenosides have antitumor, antiviral, anti-aging, immune enhancement, and other pharmacological activities, but the contents of different individual ginsenosides in herbs and their extracts are different and their pharmacological activities are different. A lot of individual ginsenosides with low contents and strong pharmacological activities are required and prepared to meet the medicinal and scientific needs. To directly improve the contents of individual ginsenosides, enzymatic preparation is a key technology. The extensive research was conducted to obtain the effective individual ginsenosides directly by enzymatic conversion. In this paper, the enzymatic conversion for preparing individual ginsenosides is reviewed to provide a theoretical basis and reference for the further development and utilization of individual ginsenosides. Key words: enzymatic method; ginsenosides; biotransformation; ginsenoside Rg1; ginsenoside Rg3 人参Panax ginseng C. A. Meryer 为五加科多 等多种药理活性，但不同皂苷单体在药材及提取 年生草本植物，人参皂苷为人参的主要活性成分， 物中量不同，其药理活性亦有差异，量低而药理 是由苷元和糖相连而成的糖苷类化合物，其属于 活性强的皂苷单体需大量制备，以满足医疗和科 萜类化合物，根据苷元不同，可将其分为 4