浅析小剂量纳洛酮复合舒芬太尼静脉自控镇痛用于硬膜外麻醉患者术后疼痛治疗观察.docVIP

精品论文 参考文献 浅析小剂量纳洛酮复合舒芬太尼静脉自控镇痛用于硬膜外麻醉患者术后疼痛治疗观察 大庆油田总医院 163000 【摘 要】目的：研究分析小剂量纳洛酮复合舒芬太尼静脉自控镇痛用于硬膜外麻醉患者术后疼痛的临床观察。方法：此次研究的对象是选取我院2010年4月～2011年3月收治的择期行硬膜外麻醉患者56例，将其临床资料进行回顾性分析，并随机分为对照组与观察组，每组各28例，均于手术结束时采用静脉自控镇痛泵入药物，比较两组患者术后不同时间点VAS评分。结果：观察组患者4h、8h和12h的VAS评分均显著低于对照组，两组比较差异有统计学意义（Plt;0.05）；观察组不良反应发生率为25.00%，明显低于对照组，两组比较具有显著性差异（Plt;0.05）。结论：小剂量纳洛酮复合舒芬太尼用于硬膜外麻醉，可有效降低患者术后疼痛，且安全性高，值得临床推广应用。 【关键词】纳洛酮；舒芬太尼；静脉自控镇痛；硬膜外麻醉 Abstract：Objective：To study the small dose of naloxone combined with sufentanil in patient-controlled intravenous analgesia in patients under epidural anesthesia clinical observation of patients with postoperative pain.Methods：the research object is selected in our hospital in April 2010 to March 2011 were undergoing epidural anesthesia were 56 cases，their clinical data were retrospective analysis，and randomly assigned to the control group and the observation group，each with 28 cases in each，at the end of surgery by patient-controlled intravenous analgesia pump into the drug and after operation were compared between the two groups at different time points VAS score.Results：observation group patients after 4h，8h and 12h VAS scores were significantly lower than those of the control group，the difference between the two groups has statistical significance（P lt; 0.05）；the incidence of adverse reactions in the observation group rate was 25.00%，significantly lower than the control group，the two groups compared with significant difference（P lt; 0.05）.Conclusion：a small dose of naloxone combined with sufentanil for epidural anesthesia，can effectively reduce the postoperative pain，and safety of high，it is worth of clinical application. Keywords：naloxone；sufentanil；analgesia；epidural anesthesia 阿片类药物是目前最常用的术后镇痛药物，但易致恶心、呕吐及呼吸抑制等并发症的发生，纳洛酮作为mu;-阿片受体拮抗药，可用于治疗阿片类药物产生的不良反应[1-2]。本研究对择期行硬膜外麻醉患者采用小剂量纳洛酮复合舒芬太尼静脉自控镇痛，取得良好效果，现将结果报道如下。 1 资料与方法 1.1 一般资料：选取我院于2010年4月～2011年3月择期行硬膜外麻醉患者56例，其中男性患者31例，女性患者25例，年龄均在19～71岁，平均年龄为（43.26plusmn;4.15）岁，体重均在43～75kg，平均体