氟芬那酸丁酯软膏治疗带状疱疹后遗神经痛的临床疗效观察.docVIP

精品论文 参考文献 氟芬那酸丁酯软膏治疗带状疱疹后遗神经痛的临床疗效观察 董颖 王翁鸣 靳卓 王博 郭敬微 (黑龙江省佳木斯市中心医院 154002) 【摘要】目的 探讨氟芬那酸丁酯软膏治疗带状疱疹后遗神经痛的临床疗效及安全性。方法 将60例患者随机分为两组，治疗组口服加巴喷丁胶囊，维生素B1，维生素B12，肌注卡介菌多糖核酸，配合窄谱中波紫外线照射，同时外用氟酚那酸丁酯软膏。对照组口服加巴喷丁胶囊，维生素B1，维生素B12，肌注卡介菌多糖核酸多糖核酸注射，配合窄谱中波紫外线照射，同时外用丁酸氢化可的松软膏。疗程为30天。治疗结束时评价治愈率，治疗结束1个月后评价复发率。结果 治疗组治愈率(70.00%)显著高于对照组(36.67%)(Plt;0.05)。治疗组复发率(6.67%)明显低于对照组(20.00%),两者比较有显著性差异(Plt;0.05)。结论 外用氟芬那酸丁酯软膏可有效缓解带状疱疹后遗神经痛的疼痛症状，且复发率低。安全有效。 【关键词】带状疱疹 后遗神经痛 氟芬那酸丁酯 紫外线光疗 【中图分类号】R969 【文献标识码】A 【文章编号】2095-1752（2014）19-0055-02 Effect of Butyl Flufenamate Ointment in the Treatment of Postherpetic Neuralgia: A Randomized Study 【Abstract】 Objective: To confirm the clinical efficacy and safety of butyl flufenamate ointment in patients with postherpetic neuralgia (PNH).Methods: 60 patients with PNH were randomized into treatment and control group. Patients in treatment group received a combined therapy of basic treatment and butyl flufenamate ointment while patients in control group basic treatment and hydrocortisone butyrate ointment. Basic treatment included oral gabapentin capsules, Vitamin B1 and B12, intramuscular injection of BCG polysaccharide nucleic acid and phototherapy of narrow band UVB. Efficacy was evaluated after 30 days of treatment. Recurrence rates were observed 1 month after the end of treatment. Results: Patients in treatment group had a significantly (Plt;0.05) higher cure rate (70.00%) compared with those in control group (36.67%).A significant difference (Plt;0.05) was observed for recurrence rates between treatment group (6.67%) and control group (20.00%). Conclusion: In patients with PNH, butyl flufenamate ointment produced significant reduction in pain and lower recurrence rate compared with corticosteroids. 【Keywords】 Postherpetic Neuralgia (PNH) Butyl Flufenamate Ointment UVB phototherapy 带状疱疹后遗神经痛(postherpetic neuralgia，PHN)是指带状疱疹的皮疹痊愈后，在原皮疹区长期存在的剧烈疼痛，临床较为常见。