盐酸川芎嗪注射液配伍心得安防治肝硬化食管静脉曲张破裂出血临床.PDFVIP

/index.php/gjicmwm GJICMWM, 2016, Vol.4, No.1 Clinical study of Ligustrazine Hydrochloride Injection combined with propranolol in prevention and treatment of esophageal varices bleeding in cirrhotic patients Gui-ghong Li, Bo-tao Jiang, Xian-fu Tang, Li Xu, Fu-bing Li, Jian-sheng Lao, Rong-hua Li, Yang Tao, Zhou Zhou Guangzhou University of Chinese Medicine Affiliated Hospital of Traditional Chinese Medicine Beibei Chongqing, Chongqing, China Received: Sep 12, 2016 Accepted: Sep 26, 2016 Published: Nov 19, 2016 DOI: 10.14725/gjicmwm.v4n1a1588 URL: /10.14725/gjicmwm.v4n1a1588 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Objective: To evaluate the efficacy and safety and mechanism of Ligustrazine Hydrochloride Injection combined with small dose propranolol in the prevention and treatment of esophageal variceal bleeding in cirrhotic patients. Methods: Control study was carried out on 32 cases of treatment group and 29 cases of control group. Hemodynamics changes of portal vein system before and after the treatment were detected by color Doppler ultrasound, and dynamic monitoring of blood pressure, heart rate, liver, renal function and rebleeding was taken. Results: The diameter of portal vein, splenic vein diameter, blood flow of portal vein, and splenic vein blood flow were decreased in the treatment group after 1 week treatment. After 4 weeks of treatment, the diameter of portal vein and splenic vein diameter and blood flow of portal vein, splenic vein blood flow in the treatment group were decreased obviously. Compared with the control group, there was significant difference (P0.05), without significant adverse reaction. The total rebleeding rate in th