更年期妇女-第三军医大学学报.DOCVIP

围绝经期甲状腺功能减退症患者焦虑及抑郁情绪的临床研究 宁宁，郑向红，王社教，封娟毅，康岩 （710004 西安交通大学医学院第二附属医院核医学科，陕西西安，中国） [摘要] 目的 以甲状腺功能减退症的围绝经期女性为研究对象，探讨甲状腺激素水平与这类人群焦虑和抑郁情绪的关系。方法 采用焦虑自评量表(Self-Rating Anxiety Scale，SAS)和抑郁自评量表(Self-Rating Depression Scale，SDS)对甲状腺功能正常、亚临床甲状腺功能减退症和临床甲状腺功能减退症的113例围绝经期女性进行评分，评估患者焦虑和抑郁的发生率以及评分与甲状腺激素的相关性。 结果 围绝经期甲状腺功能减退症女性抑郁和焦虑的发生率较对照组显著升高（P0.05）。SAS评分与游离三碘甲状腺原氨酸陕西省科技计划项目[2007K15-01(13)]epression and Anxiety Disorders in Peri-menopause Women with Hypothyroidism: a Clinical Study Ning Ning, Zheng Xianghong, Wang Shejiao, Feng Juanyi, Kang Yan ( the Second Affiliated Hospital, the Medical College of Xi’an Jiaotong University, Xi’an,Shaanxi,China) [Abstract] Objective To study the relationship with hypothyroidism and disorders of depression and anxiety in peri-menopause women. Methods 113 cases in peri-menopause period were divided into three groups: normal control, subclinical hypothyroidism and overt hypothyroidism. Anxiety and depression of them were investigated with Self-rating anxiety scale (SAS) and Self- rating depression scale (SDS). The correlation between thyroid hormones and anxiety/depression disorders was observed. Results The prevalence of anxiety and depression disorders in peri-menopause women with hypothyroidism was higher than control group（P0.05）. SAS scores had significantly negative and positive correlation with free thyroxine (FT4）（P0.001）and thyroid stimulating hormone(TSH) （P0.01）respectively. SDS scores had significantly negative correlation with free triiodothyronine(FT3) and FT4（P0.001）, and had positive correlation with thyroid stimulating hormone(TSH)(P0.01). Conclusion The prevalence of anxiety and depression disorders in peri-menopause women with hypothyroidism increased. There was significant correlation between the degree of anxiety/depression disorders and thyroid hormones level. [key words] peri-menopause; hypothyroidism; anxiety; depression Supported by the Science and Technology Research Foundation of Shaanxi[2007K15-01(13)]. Correspondin