年产一亿片维生素b6生产工艺设计.docVIP

摘 要 维生素B6通常用于治疗妊娠呕吐、药物性胃肠反应和预防抗结核药异烟肼毒副作用等,现代医学发现其还具有止痛、防治肾结石、防治冠心痛、高血压、阻止脑血栓形成、预防癌症、治疗内源性抑郁症等症状，在临床应用广泛，主要有维生素B6片和注射液。目前我国维生素B6的合成及生产已比较完善。 本设计为年产一亿片维生素B6的工艺设计，包括维生素B6的产品概述及其湿法制粒的过程，工艺路线，能量衡算，物料衡算，并根据物料衡算的资料选择具有相应生产能力的设备型号，并根据设备型号进行车间布置设计，最后为药厂的安全生产与三废处理及其综合利用等内容。附录部分包括带控制点工艺流程图，车间布置图，主要设备图，工艺流程图。 关键词:维生素B6 片剂 工艺设计 车间布置 ABSTRACT Vitamin B6 is often used to treat vomiting of pregnancy, drug-induced gastrointestinal reactions and prevention anti-TB drugs simonized side effects, etc. Modern Medicine has found that it also has analgesic, prevention and treatment of kidney stones, prevention coronary heart and high blood pressure, Preventing cerebral thrombosis and cancer, treatment of endogenous depression symptoms. It is widely used in clinical practice, divided into Vitamin B6 tablets and Vitamin B6 Injection. At present, the production of synthetic vitamin B6 have been more perfect in our country. This design is for the annual production capacity of 100 million tablets of vitamin B6 manufacturing workshop. The body parts of vitamin B6 Instructions, including an overview of the process of wet granulation, discusses the process route, energy balance, about the characteristics of the drug, and then material balance. We choose production capacity with the corresponding equipment model based on the material balance,decide workshop Layout design based on Equipment Type.Finally, it introduces the safety of pharmaceutical production , Waste treatment and the comprehensive utilization. The appendix includes the control points with a flow chart, workshop layout, the main instrument diagrams, process flow diagrams. Key words：vitamin B6 ;tablet ; process design ; workshop layout 第一章 绪论吸收，原型药与血浆蛋白几乎不结合，转化为活性产物磷酸吡哆醛可较完全的与血浆蛋白结合，血浆半衰期可长达15-20天。本品在肝内代谢，经肾排出。磷酸吡哆醛可透过胎盘，并经乳汁泌出。 维生素B6在红细胞内为磷酸吡哆醛，后者作为机体不可缺乏的辅酶，可参与氨基酸，碳水化合物及脂肪的正常代谢。此外维生素B6还参与色氨酸将烟酸转化为5—羟色胺的反应。并可刺激白细胞的生长，是形成血红蛋白所需要的物质。 维生素B6缺乏的症状主要表现在