阴滋病.full.pdf.docVIP

CLINICAL AND VACCINE IMMUNOLOGY, July 2010, p. 1132–1138 Vol. 17, No. 7 1556-6811/10/$12.00 doi:10.1128/CVI.00053-10 Copyright ? 2010, American Society for Microbiology. All Rights Reserved. Disseminated Penicilliosis, Recurrent Bacteremic Nontyphoidal Salmonellosis, and Burkholderiosis Associated with Acquired Immunodeficiency Due to Autoantibody against Gamma Interferon Bone Siu-Fai Tang,1 Jasper Fuk-Woo Chan,2 Min Chen,2 Owen Tak-Yin Tsang,3 M. Y. Mok,4 Raymond Wai-Man Lai,5 Rodney Lee,6 Tak-Lun Que,7 Herman Tse,2 Iris Wai-Sum Li,2 Kelvin Kai-Wang To,2 Vincent Chi-Chung Cheng,2 Eric Yuk-Tat Chan,8 Bojian Zheng,2 and Kwok-Yung Yuen2* Department of Pathology, Hong Kong Sanatorium and Hospital,1 and Department of Microbiology, Queen Mary Hospital,2 University of Hong Kong; Department of Medicine and Geriatrics, Princess Margaret Hospital,3 and Department of Medicine, Queen Mary Hospital,4 University of Hong Kong; and Department of Microbiology, Prince of Wales Hospital,5 Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital,6 Department of Clinical Pathology, Tuen Mun Hospital,7 and Department of Pathology, Queen Mary Hospital,8 Hong Kong Special Administrative Region, China Received 8 February 2010/Returned for modification 5 March 2010/Accepted 19 April 2010 Acquired immunodeficiency due to autoantibody against gamma interferon has recently been associated with opportunistic nontuberculous mycobacteriosis, especially among Southeast Asians. We report another 8 cases, all except one apparently immunocompetent hosts who suffered from concomitant or sequential infections by other intracellular pathogens causing penicilliosis, extraintestinal nontyphoidal salmonellosis, and burkhold-eriosis. The only case with an underlying immunodeficiency syndrome had systemic lupus erythematosus that was quiescent throughout the multiple infective episodes. Eight out of 10 (80.0%) patients with serological evidence of penicilliosis, 5 out of 7 (71.4%) with cult