4-硫胸苷的合成新方法.pdfVIP

Studies in Synthetic Chemistry 合成化学研究, 2015, 3(3), 70-73 Published Online September 2015 in Hans. /journal/ssc /10.12677/ssc.2015.33011 New Method for the Synthesis of 4-Thiothymidine Defeng Yan, Lingshuang He, Kedong Ma, Xiaohui Zhang, Depeng Li Institute of Environment and Chemical Engineering, Dalian University, Dalian Liaoning Email: yandefeng1991@ th th th Received: Aug. 29 , 2015; accepted: Sep. 13 , 2015; published: Sep. 16 , 2015 Copyright © 2015 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract 4-Thiothymidine combined with UVA (light shading effect with long-wave ultraviolet) as a poten- tially novel therapy for cancer provides a new way, UVA-sensitive 4-thiothymidine was obtained through the study of the modification of thiothymidine at 4-position, and reached the role of treatment of tumor cells under the synergy of UVA. In order to obtain 4-Thiothymidine drugs with new optical properties, triazole and P2S5 are used in previously reported methods. In this study, Lawesson reagent was adopted to prepare 4-thiothymidine. Under the optimized conditions, the reaction time was significantly reduced and the yield increased. The structure of the product was characterized by 1H-NMR and 13C-NMR. Keywords 4-Thiothymidine, Lawesson Reagent, Synthesis, Antitumor Activity 4-硫胸苷的合成新方法 闫德峰，赫玲爽，马克东，张晓辉，李德鹏 大连大学环境与化学工程学院，辽宁 大连 Email: yandefeng1991@ 收稿日期：2015年8月29 日；录用日期：2015年9月13 日；发布日期：2015年9月16 日 文章引用: 闫德峰, 赫玲爽, 马克东, 张晓辉, 李德鹏 (2015) 4-硫胸苷的合成新方法. 合成化学研究, 3, 70-73. /10.12677/ssc.2015.33011