design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules脑膜炎球菌疫苗的设计和评价通过基于结构修改宿主和病原体分子.pdfVIP

下载本文档

1
0
约8.22万字
约 13页
2017-09-12 发布于上海
举报
版权申诉

design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules脑膜炎球菌疫苗的设计和评价通过基于结构修改宿主和病原体分子.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules脑膜炎球菌疫苗的设计和评价通过基于结构修改宿主和病原体分子

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules Steven Johnson1., Lionel Tan2., Stijn van der Veen1., Joseph Caesar1., Elena Goicoechea De Jorge3., 1. 4 1 1 2 2 Rachel J. Harding , Xilian Bai , Rachel M. Exley , Philip N. Ward , Nicola Ruivo , Kaushali Trivedi , 1 1 1 5 6 4 Elspeth Cumber , Rhian Jones , Luke Newham , David Staunton , Rafael Ufret-Vincenty , Ray Borrow , 3 1 1,2 Matthew C. Pickering *, Susan M. Lea *, Christoph M. Tang * 1 Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom, 2 Centre for Molecular Microbiology and Infection, Imperial College, London, United Kingdom, 3 Centre for Complement and Inflammation Research (CCIR), Department of Medicine, Imperial College, London, United Kingdom, 4 Vaccine Evaluation Unit, Public Health Laboratory, Manchester Medical Microbiology Partnership, Manchester, United Kingdom, 5 Department of Biochemistry, University of Oxford, Oxford, United Kingdom, 6 Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, United States of America Abstract Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a key antigen that elicits protective immunity against the meningococcus and recruits the host complement regulator, fH. As the high affinity interaction between fHbp and fH could