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design and synthesis of binding growth factors设计和合成具有约束力的生长因子.pdf

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design and synthesis of binding growth factors设计和合成具有约束力的生长因子

Int. J. Mol. Sci. 2012, 13, 6053-6072; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Design and Synthesis of Binding Growth Factors Seiichi Tada, Takashi Kitajima and Yoshihiro Ito * Nano Medical Engineering Laboratory, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; E-Mails: s-tada@riken.jp (S.T.); t-kitajima@riken.jp (T.K.) * Author to whom correspondence should be addressed; E-Mail: y-ito@riken.jp; Tel.: +81-48-467-9302; Fax: +81-48-467-9300. Received: 5 March 2012; in revised form: 10 April 2012 / Accepted: 9 May 2012 / Published: 18 May 2012 Abstract: Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches. Keywords: growth factor; immobilization; protein engineering; tissue engineering; collagen; peptide ligation 1. Introduction Growth factors are involved in the regulation of a va