有哪些信誉好的足球投注网站deletion of munc18-1 in 5-ht neurons results in rapid degeneration of the 5-ht system and early postnatal lethality删除munc18-1在5 - 5 -神经元导致快速退化系统和早期产后杀伤力.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
deletion of munc18-1 in 5-ht neurons results in rapid degeneration of the 5-ht system and early postnatal lethality删除munc18-1在5 - 5 -神经元导致快速退化系统和早期产后杀伤力
Deletion of Munc18-1 in 5-HT Neurons Results in Rapid Degeneration of the 5-HT System and Early Postnatal Lethality ¤ Jacobus J. Dudok , Alexander J. A. Groffen, Ruud F. T. Toonen, Matthijs Verhage* Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands Abstract The serotonin (5-HT) system densely innervates many brain areas and is important for proper brain development. To specifically ablate the 5-HT system we generated mutant mice carrying a floxed Munc18-1 gene and Cre recombinase driven by the 5-HT-specific serotonin reuptake transporter (SERT) promoter. The majority of mutant mice died within a few days after birth. Immunohistochemical analysis of brains of these mice showed that initially 5-HT neurons are formed and the cortex is innervated with 5-HT projections. From embryonic day 16 onwards, however, 5-HT neurons started to degenerate and at postnatal day 2 hardly any 5-HT projections were present in the cortex. The 5-HT system of mice heterozygous for the floxed Munc18-1 allele was indistinguishable from control mice. These data show that deletion of Munc18-1 in 5-HT neurons results in rapid degeneration of the 5-HT system and suggests that the 5-HT system is important for postnatal survival. Citation: Dudok JJ, Groffen AJA, Toonen RFT, Verhage M (2011) Deletion of Munc18-1 in 5-HT Neurons Results in Rapid Degeneration of the 5-HT System and Early Postnatal Lethality. PLoS ONE 6(11): e28137. doi:10.1371/journal.pone.0028137 Editor: Pascale Chavis, INSERM U901, France Received January 8, 2011; Accepted November 2, 2011; Published November 29, 2011 Copyright: 2011 Dudok et al. This is an open-access article distributed under the terms of the Creative Commons Attribution
您可能关注的文档
- decreased proliferation kinetics of mouse myoblasts overexpressing frg1降低小鼠成肌细胞的增殖动力学overexpressing frg1.pdf
- decreased spontaneous eye blink rates in chronic cannabis users evidence for striatal cannabinoid-dopamine interactions减少自发眨眼率长期吸食大麻的证据纹状体cannabinoid-dopamine交互.pdf
- decreased premotor cortex volume in victims of urban violence with posttraumatic stress disorder减少运动前区皮层体积与创伤后应激障碍城市暴力的受害者.pdf
- decreased th1-type inflammatory cytokine expression in the skin is associated with persisting symptoms after treatment of erythema migransth1-type减少皮肤炎症细胞因子表达与坚持治疗后症状的游走性红斑.pdf
- decreased ratio of treg cells to th17 cells correlates with hbv dna suppression in chronic hepatitis b patients undergoing entecavir treatment减少treg细胞比th17细胞与hbv dna抑制在接受恩替卡韦治疗慢性乙型肝炎患者.pdf
- decreased mdm2 expression inhibits tumor development and extends survival independent of arf and dependent on p53减少mdm2表达抑制肿瘤发展和扩展生存arf的独立和依赖p53.pdf
- decreased expression of the arid1a gene is associated with poor prognosis in primary gastric cancer减少arid1a基因的表达与原发性胃癌预后不良有关.pdf
- decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling探索性活动下降15 q复制综合征小鼠模型;.pdf
- deductive biocomputing演绎生物运算.pdf
- deep annotation of populus trichocarpa micrornas from diverse tissue sets深注释的杨树trichocarpa microrna来自不同组织的集.pdf
- deletion of the basement membrane heparan sulfate proteoglycan type xviii collagen causes hypertriglyceridemia in mice and humans删除的基底膜硫酸乙酰肝素蛋白聚糖十八型胶原蛋白在小鼠和人类引起高甘油三酯血症.pdf
- delineation of stage specific expression of plasmodium falciparum eba-175 by biologically functional region ii monoclonal antibodies界定阶段特定的表达恶性疟原虫eba - 175 ii单克隆抗体生物功能区域.pdf
- delivery of iron-sulfur clusters to the hydrogen-oxidizing [nife]-hydrogenases in escherichia coli requires the a-type carrier proteins erpa and isca交付iron-sulfur集群在大肠杆菌种氢氧(镍铁)-hydrogenases需要a类型载体蛋白erpa和isca.pdf
- delocalization of electrons in strong insulators at high dynamic pressures离域电子在高动态压力强大的绝缘体.pdf
- delocalization and sensitivity of quantum wavepacket in coherently perturbed kicked anderson model移位和敏感的量子波包在连贯地摄动踢安德森模型.pdf
- delta-like 4 differentially regulates murine cd4+ t cell expansion via bmi1delta-like 4不同调节小鼠cd4 + t细胞通过bmi1扩张.pdf
- demand forecast of petroleum product consumption in the chinese transportation industry需求预测的石油产品消费在中国运输行业.pdf
- deletion of the rnaseiii enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations删除rnaseiii酶的帽子在甲状腺滤泡细胞导致甲状腺功能减退与肿瘤改变的迹象.pdf
- demand side management for stand-alone hybrid power systems based on load identification需求侧管理独立的基于载荷识别的混合动力系统.pdf
- demand for zn2+ in acid-secreting gastric mucosa and its requirement for intracellular ca2+zn2 +需求acid-secreting胃粘膜及其胞内游离钙与要求.pdf
文档评论（0）