decreased levels of active smad2 correlate with poor prognosis in gastric cancer减少主动smad2水平与胃癌预后不良.pdfVIP

Decreased Levels of Active SMAD2 Correlate with Poor Prognosis in Gastric Cancer 1 . 2. 3 1 1 2 4 4 Yijun Wu * , Qi Li , Xinhui Zhou , Jiren Yu , Yunchuan Mu , Stefan Munker , Chengfu Xu , Zhe Shen , ¨ 2,5 2 6 6 7 7 8 Roman Mullenbach , Yan Liu , Li Li , Norbert Gretz , Derek Zieker , Jun Li , Kouichi Matsuzaki , 4 2. 2 . Youming Li , Steven Dooley , Honglei Weng * 1 Department of General Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2 Molecular Hepatology - Alcohol Associated Diseases, II, Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, Mannheim, Germany, 3 Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 4 Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, 5 Department of Medicine II, Saarland University Hospital, Saarland University, Homburg, Germany, 6 Medical Research Center, Medical Faculty ¨ ¨ Mannheim, University of Heidelberg, Mannheim, Germany, 7 General, Visceral Surgery and Transplantation, University Hospital Tubingen, Tubingen, Germany, 8 Departments of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan Abstract Background: TGF- b plays a dual role in the progression of human cancer. During the