有哪些信誉好的足球投注网站decolonisation of mrsa, s. aureus and e. coli by cold-atmospheric plasma using a porcine skin model in vitro去殖民化的耐甲氧西林金黄色葡萄球菌,金黄色葡萄球菌和大肠杆菌cold-atmospheric使用猪血浆体外皮肤模型.pdfVIP
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decolonisation of mrsa, s. aureus and e. coli by cold-atmospheric plasma using a porcine skin model in vitro去殖民化的耐甲氧西林金黄色葡萄球菌,金黄色葡萄球菌和大肠杆菌cold-atmospheric使用猪血浆体外皮肤模型
Decolonisation of MRSA, S. aureus and E. coli by Cold- Atmospheric Plasma Using a Porcine Skin Model In Vitro 1 2 2 1 1 2 Tim Maisch *, Tetsuji Shimizu , Yang-Fang Li , Julia Heinlin , Sigrid Karrer , Gregor Morfill , Julia L. Zimmermann2 1 Department of Dermatology, Regensburg University Hospital, Regensburg, Bavaria, Germany, 2 Max Planck Institute for Extraterrestrial Physics, Garching, Bavaria, Germany Abstract In the last twenty years new antibacterial agents approved by the U.S. FDA decreased whereas in parallel the resistance situation of multi-resistant bacteria increased. Thus, community and nosocomial acquired infections of resistant bacteria led to a decrease in the efficacy of standard therapy, prolonging treatment time and increasing healthcare costs. Therefore, the aim of this work was to demonstrate the applicability of cold atmospheric plasma for decolonisation of Gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Methicillin-sensitive Staphylococcus aureus) and Gram-negative bacteria (E. coli) using an ex vivo pig skin model. Freshly excised skin samples were taken from six month old female pigs (breed: Pietrain). After application of pure bacteria on the surface of the explants these were treated with cold atmospheric plasma for up to 15 min. Two different plasma devices were evaluated. A decolonisation efficacy of 3 log10 steps was achieved already after 6 min of plasma treatment. Longer plasma treatment times achieved a killing rate of 5 log10 steps independently from the applied bacteria strains. Histological evaluations of untreated and treated skin areas upon cold atmospheric plasma treatment within 24 h showed no morpholog
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