creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults一水肌酸和共轭亚油酸改善力量和身体成分在老年人抵抗运动后.pdfVIP

Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults 1 1 1 1 1 1 2 3,4 Mark Tarnopolsky *, Andrew Zimmer , Jeremy Paikin , Adeel Safdar , Alissa Aboud , Erin Pearce , Brian Roy , Timothy Doherty 1 Department of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada, 2 Department of Physical Education and Kinesiology, Brock University, St. Catharines, Ontario, Canada, 3 Department of Clinical Neurological Sciences, The University of Western Ontario, London, Ontario, Canada, 4 Department of Physical Medicine and Rehabilitation, The University of Western Ontario, London, Ontario, Canada Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (.65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (N-telopeptides). Exercise training improved all measurements of functional capacity (P,0.05) and strength (P,0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P,0.05).