cranial irradiation alters dendritic spine density and morphology in the hippocampus颅辐照改变海马树突棘密度和形态.pdfVIP

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cranial irradiation alters dendritic spine density and morphology in the hippocampus颅辐照改变海马树突棘密度和形态.pdf

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cranial irradiation alters dendritic spine density and morphology in the hippocampus颅辐照改变海马树突棘密度和形态

Cranial Irradiation Alters Dendritic Spine Density and Morphology in the Hippocampus Ayanabha Chakraborti1,4, Antino Allen1,4, Barrett Allen1,4, Susanna Rosi1,3,4, John R. Fike1,2,4* 1 Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America, 3 Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, California, United States of America, 4 Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California, United States of America Abstract Therapeutic irradiation of the brain is a common treatment modality for brain tumors, but can lead to impairment of cognitive function. Dendritic spines are sites of excitatory synaptic transmission and changes in spine structure and number are thought to represent a morphological correlate of altered brain functions associated with hippocampal dependent learning and memory. To gain some insight into the temporal and sub region specific cellular changes in the hippocampus following brain irradiation, we investigated the effects of 10 Gy cranial irradiation on dendritic spines in young adult mice. One week or 1 month post irradiation, changes in spine density and morphology in dentate gyrus (DG) granule and CA1 pyramidal neurons were quantified using Golgi staining. Our results showed that in the DG, there were significant reductions in spine density at both 1 week (11.9%) and 1 month (26.9%) after irradiation. In contrast, in the basal dendrites of CA1 pyramidal neurons, irradiation resulted in a significant reduction (18.7%) in spine density only at 1