daily timed sexual interaction induces moderate anticipatory activity in mice每日定时性的相互作用引起的预期活动在老鼠身上.pdfVIP

Daily Timed Sexual Interaction Induces Moderate Anticipatory Activity in Mice 1 ´ 2 1 1 Cynthia T. Hsu , Piotr Dollar , Daniel Chang , Andrew D. Steele * 1 Broad Fellows Program in Brain Circuitry, Division of Biology, California Institute of Technology, Pasadena, California, United States of America, 2 Division of Engineering and Applied Science, California Institute of Technology, Pasadena, California, United States of America Abstract Anticipation of resource availability is a vital skill yet it is poorly understood in terms of neuronal circuitry. Rodents display robust anticipatory activity in the several hours preceding timed daily access to food when access is limited to a short temporal duration. We tested whether this anticipatory behavior could be generalized to timed daily social interaction by examining if singly housed male mice could anticipate either a daily novel female or a familiar female. We observed that anticipatory activity was moderate under both conditions, although both a novel female partner and sexual experience are moderate contributing factors to increasing anticipatory activity. In contrast, restricted access to running wheels did not produce any anticipatory activity, suggesting that an increase in activity during the scheduled access time was not sufficient to induce anticipation. To tease apart social versus sexual interaction, we tested the effect of exposing singly housed female mice to a familiar companion female mouse daily. The female mice did not show anticipatory activity for restricted female access, despite a large amount of social interaction, suggesting that daily timed social interaction between mice of the same gender is insufficient to induce anticipatory activity. Our study demonstrates that male mice will show anticipator