有哪些信誉好的足球投注网站continuous regional arterial infusion with fluorouracil and octreotide attenuates severe acute pancreatitis in a canine model连续区域动脉灌注与氟尿嘧啶octreotide变弱严重急性胰腺炎犬模型.pdfVIP
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continuous regional arterial infusion with fluorouracil and octreotide attenuates severe acute pancreatitis in a canine model连续区域动脉灌注与氟尿嘧啶octreotide变弱严重急性胰腺炎犬模型
Continuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model 1. 2. 1 1 1 2 Meng Tao Zhou , Bi Cheng Chen , Hong Wei Sun , Yue Peng Jin , Fa Jing Yang , Xing Zhang , 3 1 Roland Andersson , Qi Yu Zhang * 1 Department of Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang Province, China, 2 Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejaing Province, China, 3 Department of Surgery, Clinical Sciences Lund, Lund University and Skane University Hospital, Lund, Sweden Abstract Aim: To investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). Materials and Methods: The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, a-tumor necrosis factor (TNF-a), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto- prostaglandin F1a were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. Results: Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels o
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