comparing pandemic to seasonal influenza mortality moderate impact overall but high mortality in young children比较流行的季节性流感死亡率中度影响整体但在儿童高死亡率.pdfVIP

Comparing Pandemic to Seasonal Influenza Mortality: Moderate Impact Overall but High Mortality in Young Children 1 1 1,2 1 Cees C. van den Wijngaard *, Liselotte van Asten , Marion P. G. Koopmans , Wilfrid van Pelt , Nico J. D. 3 1 1 1 1 ´ 4 Nagelkerke , Cornelia C. H. Wielders , Alies van Lier , Wim van der Hoek , Adam Meijer , Ge A. Donker , 1 5 1,6 1,6 Frederika Dijkstra , Carel Harmsen , Marianne A. B. van der Sande , Mirjam Kretzschmar 1 National Institute for Public Health and the Environment, Center for Infectious Disease Control, Bilthoven, The Netherlands, 2 Erasmus Medical Center, Rotterdam, The Netherlands, 3 United Arab Emirates University, Al-Ain, United Arab Emirates, 4 NIVEL, Netherlands Institute of Health Services Research, Utrecht, The Netherlands, 5 Statistics Netherlands, The Hague, The Netherlands, 6 Julius Centre for Health Sciences Primary Care, University Medical Centre, Utrecht, The Netherlands Abstract Background: We assessed the severity of the 2009 influenza pandemic by comparing pandemic mortality to seasonal influenza mortality. However, reported pandemic deaths were laboratory-confirmed – and thus an underestimation – whereas seasonal influenza mortality is often more inclusively estimated. For a valid comparison, our study used the same statistical methodology and data types to estimate pandemic and seasonal influenza mortality. Methods and Finding