combined effects of 19 common variations on type 2 diabetes in chinese results from two community-based studies19的共同变化2型糖尿病在中国从两个以社区为基础的研究结果.pdfVIP

Combined Effects of 19 Common Variations on Type 2 Diabetes in Chinese: Results from Two Community-Based Studies 1,2 2 2 3 2 2 2 1,2 2 Min Xu , Yufang Bi , Yu Xu , Bing Yu , Yun Huang , Lina Gu , Yaohua Wu , Xiaolin Zhu , Mian Li , 2 2 2 1,2,4 1,2,4 Tiange Wang , Aiyun Song , Jianing Hou , Xiaoying Li , Guang Ning * 1 State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2 Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3 Department of Molecular Clinical Genetics, Royal Prince Alfred Hospital and Central Clinical School, The University of Sydney, Sydney, Australia, 4 Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China Abstract Background: Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese. Methods/Principal Findings: Subjects were enrolled in: (1) a case-control study including 1825 subjects with T2DM, 1487 with IGR and 2200 with normal glucose regulation; and (2) a prospective cohort with 734 n