有哪些信誉好的足球投注网站combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures结合药物作用的2-phenylimidazo(2,1 b)苯并噻唑衍生物对癌症细胞根据其致癌的分子签名.pdfVIP
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combined drug action of 2-phenylimidazo[2,1-b]benzothiazole derivatives on cancer cells according to their oncogenic molecular signatures结合药物作用的2-phenylimidazo(2,1 b)苯并噻唑衍生物对癌症细胞根据其致癌的分子签名
Combined Drug Action of 2-Phenylimidazo[2,1- b]Benzothiazole Derivatives on Cancer Cells According to Their Oncogenic Molecular Signatures 1 1 1 1 1 Alessandro Furlan , Benjamin Roux , Fabienne Lamballe , Filippo Conti , Nathalie Issaly , 1 1 1 1 2 Fabrice Daian , Jean-Franc¸ois Guillemot , Sylvie Richelme , Magali Contensin , Joan Bosch , 3 4 1 1 Daniele Passarella , Oreste Piccolo , Rosanna Dono , Flavio Maina * 1 Aix-Marseille Univ, IBDML, CNRS UMR 7288, Marseille, France, 2 Laboratory of Organic Chemistry, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of ` Barcelona, Barcelona, Spain, 3 Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, Milano, Italy, 4 Studio di consulenza scientifica, Sirtori (LC), Italy Abstract The development of targeted molecular therapies has provided remarkable advances into the treatment of human cancers. However, in most tumors the selective pressure triggered by anticancer agents encourages cancer cells to acquire resistance mechanisms. The generation of new rationally designed targeting agents acting on the oncogenic path(s) at multiple levels is a promising approach for molecular therapies. 2-phenylimidazo[2,1-b]benzothiazole derivatives have been highlighted for their properties of targeting oncogenic Met receptor tyrosine kinase (RTK) signaling. In this study, we evaluated the mechanism of action of one of the most active imi
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