combining spatial-temporal and phylogenetic analysis approaches for improved understanding on global h5n1 transmission结合时空和系统发育分析方法改进的理解全球h5n1病毒的传播.pdfVIP

Combining Spatial-Temporal and Phylogenetic Analysis Approaches for Improved Understanding on Global H5N1 Transmission 1,2 3,4 5 6 7 7 8 Lu Liang , Bing Xu , Yanlei Chen , Yang Liu , Wuchun Cao , Liqun Fang , Limin Feng , Michael F. Goodchild9, Peng Gong1,2,5* 1 State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications, Chinese Academy of Sciences, Beijing Normal University, Beijing, China, 2 Center for Earth System Science, Tsinghua University, Beijing, China, 3 Department of Geography, University of Utah, Salt Lake City, Utah, United States of America, 4 Department of Environmental Science and Engineering, Tsinghua University, Beijing, China, 5 Department of Environmental Science, Policy and Management, University of California, Berkeley, California, United States America, 6 Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland, 7 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China, 8 Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education, College of Life Science, Beijing Normal University, Beijing, China, 9 Department of Geography, University of California Santa Barbara, Santa Barbara, California, United States of America Abstract Background: Since late 2003, the highly pathogenic influenza A H5N1 had initiated several outbreak waves that swept across the Eurasia and Africa continents. Getting prepared for reassortment or mutation of H5N1 viruses has become a global priority. Although the spreading mechanism of H5N1 has been studied from different perspectives