cohesin in oocytes—tough enough for mammalian meiosiscohesin oocytes-tough足够的哺乳动物减数分裂.pdfVIP

Genes 2010, 1, 495-504; doi:10.3390/genes1030495 OPEN ACCESS genes ISSN 2073-4425 /journal/genes Review Cohesin in Oocytes—Tough Enough for Mammalian Meiosis? Ekaterina Revenkova 1, Caroline Adelfalk 2 and Rolf Jessberger 2,* 1 Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1020, New York, NY 10029, USA; E-Mail: ekaterina.revenkova@ 2 Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fiedlerstr. 42, MTZ, D-01307 Dresden, Germany; E-Mail: caroline.adelfalk@tu-dresden.de * Author to whom correspondence should be addressed; E-Mail: rolf.jessberger@tu-dresden.de; Tel.: +49-351-458-6446; Fax: +49-351-458-6305. Received: 11 October 2010; in revised form: 22 November 2010 / Accepted: 27 November 2010 / Published: 13 December 2010 Abstract: Sister chromatid cohesion is essential for cell division. During meiosis, it is also required for proper synapsis of pairs of sister chromatids and for chiasma formation and maintenance. Since mammalian oocytes remain arrested in late prophase for a very long period—up to five decades in humans—the preservation of cohesion throughout this period is a formidable challenge. Mouse models with cohesin deficiencies and aging wild-type mice showed that this challenge is not fully met: cohesion weakens and deteriorates with increasing age. These recent findings have highly significant implications for our comprehension of the gene