blood cell telomere length is a dynamic feature血液细胞端粒长度是一个动态的特性.pdfVIP

Blood Cell Telomere Length Is a Dynamic Feature 1 ¨ 1 2 2 1 Ulrika Svenson , Katarina Nordfjall , Duncan Baird , Laureline Roger , Pia Osterman , Mai-Lis 3 ¨ 1 Hellenius , Goran Roos * ˚ ˚ 1 Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden, 2 Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom, 3 Cardiology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Abstract There is a considerable heterogeneity in blood cell telomere length (TL) for individuals of similar age and recent studies have revealed that TL changes by time are dependent on TL at baseline. TL is partly inherited, but results from several studies indicate that e.g. life style and/or environmental factors can affect TL during life. Collectively, these studies imply that blood cell TL might fluctuate during a life time and that the actual TL at a defined time point is the result of potential regulatory mechanism(s) and environmental factors. We analyzed relative TL (RTL) in subsequent blood samples taken six months apart from 50 individuals and found significant associations between RTL changes and RTL at baseline. Individual RTL changes per month were more pronounced than the changes recorded in a previously studied population analyzed after 10 years’ follow up. The data argues for an oscillating TL pattern which levels out at longer follow up times. In a separate group of five blood donors, a marked telomere loss was demonstrated within a six month period for one donor where after TL was stabilized. PCR determined