zinc hyperaccumulation in squirrelfish (holocentrus adscenscionis) and its role in embryo viability锌超富集金鳞鱼(holocentrus adscenscionis)及其在胚胎发育能力.pdfVIP

Zinc Hyperaccumulation in Squirrelfish (Holocentrus adscenscionis) and Its Role in Embryo Viability 1 . 2. 3 4 4,5 E. David Thompson * , Gregory D. Mayer , Chris N. Glover , Tom Capo , Patrick J. Walsh , Christer Hogstrand4,6 1 Department of Biological Sciences, Northern Kentucky University, Highland Heights, Kentucky, United States of America, 2 The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, United States of America, 3 School of Biological Sciences, University of Canterbury, Christchurch, New Zealand, 4 Division of Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, Florida, United States of America, 5 Department of Biology, University of Ottawa, Ottawa, Ontario, Canada, 6 Diabetes and Nutritional Sciences Division, King’s College London, London, United Kingdom Abstract Female squirrelfish (Fam. Holocentridae) can accumulate and temporarily sequester copious amounts of zinc (Zn) in their livers. There, it is initially compartmentalized before a subsequent, estrogen-triggered redistribution to the ovaries. Here we show that cellular uptake of Zn is also influenced by estrogen signaling, and that estrogen increases concentrations of the plasma Zn-binding protein vitellogenin (VTG). However, estrogen-mediated increases in VTG are not sufficient to accommodate the magnitude of hepato-ovarian Zn transfer in female squirrelfish (Holocentrus adscensionis). These findings suggest that holocentrids have acquired the ability to use hormonal cues to drive hepatic uptake and storage of Zn, signal for its physiological redistr