biosafety of non-surface modified carbon nanocapsules as a potential alternative to carbon nanotubes for drug delivery purposes生物安全不修改碳nanocapsules作为潜在的替代碳纳米管用于药物输送.pdfVIP

Biosafety of Non-Surface Modified Carbon Nanocapsules as a Potential Alternative to Carbon Nanotubes for Drug Delivery Purposes 1 2,4 2,4{ 3 1 Alan C. L. Tang , Gan-Lin Hwang , Shih-Jung Tsai , Min-Yao Chang , Zack C. W. Tang , Meng-Da 5 5 6 1,3,4,5,6,7 Tsai , Chwan-Yao Luo , Allan S. Hoffman , Patrick C. H. Hsieh * 1 Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, 2 Nano-Powder and Thin Film Technology Center, Industrial Technology Research Institute, Tainan, Taiwan, 3 Institute of Biomedical Engineering, National Cheng Kung University Hospital, Tainan, Taiwan, 4 Center for Micro/Nano Science and Technology, National Cheng Kung University Hospital, Tainan, Taiwan, 5 Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan, 6 Department of Bioengineering, University of Washington, Seattle, Washington, United States of America, 7 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan Abstract Background: Carbon nanotubes (CNTs) have found wide success in circuitry, photovoltaics, and other applications. In contrast, several hurdles exist in using CNTs towards applications in drug delivery. Raw, non-modified CNTs are widely known for their toxicity. As such, many have attempted to reduce CNT toxicity for intravenous drug delivery purposes by post-process surface modification. Alternatively, a novel sphere-like carbon nanocapsule (CNC) developed by the arc- discharge method holds similar electric and thermal conductivities, as well as high strength. This study investigate