有哪些信誉好的足球投注网站zebrafish cyclin-dependent protein kinase–like 1 (zcdkl1) identification and functional characterization斑马鱼细胞周期蛋白依赖性蛋白kinase-like 1(zcdkl1)识别和功能描述.pdfVIP
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zebrafish cyclin-dependent protein kinase–like 1 (zcdkl1) identification and functional characterization斑马鱼细胞周期蛋白依赖性蛋白kinase-like 1(zcdkl1)识别和功能描述
Int. J. Mol. Sci. 2011, 12, 3606-3617; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Zebrafish Cyclin-Dependent Protein Kinase–Like 1 (zcdkl1): Identification and Functional Characterization Li-Sung Hsu 1,2,*, Cyong-Jhih Liang 1, Chen-Yuan Tseng 1, Chi-Wei Yeh 1 and Jen-Ning Tsai 3 1 Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan; E-Mails: choch7211@ (C.-J.L.); rockforever1102@ (C.-Y.T.); n131716@ (C.-W.Y.) 2 Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan 3 School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan; E-Mail: zgsk3@ * Author to whom correspondence should be addressed; E-Mail: lshsu405@.tw; Tel.: +886-4ext. 11682; Fax: +886-4 Received: 22 April 2011; in revised form: 19 May 2011 / Accepted: 22 May 2011 / Published: 3 June 2011 Abstract: The cyclin-dependent protein kinase family regulates a wide range of cellular functions such as cell cycle progression, differentiation, and apoptosis. In this study, we identified a zebrafish cyclin-dependent protein kinase-like 1 protein called zebrafish cdkl1 (zcdkl1), which shared a high degree of homology and conserved synteny with mammalian orthologs. zcdkl1 exhibited abilities for phosphorylation of myelin basic protein and histone H1. RT-PCR analysis revealed that zcdkl
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