biophysical properties of lumbricus terrestris erythrocruorin and its potential use as a red blood cell substitute生物物理属性地龙的erythrocruorin及其潜在使用代替红细胞.pdfVIP

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biophysical properties of lumbricus terrestris erythrocruorin and its potential use as a red blood cell substitute生物物理属性地龙的erythrocruorin及其潜在使用代替红细胞.pdf

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biophysical properties of lumbricus terrestris erythrocruorin and its potential use as a red blood cell substitute生物物理属性地龙的erythrocruorin及其潜在使用代替红细胞

J. Funct. Biomater. 2012, 3, 49-60; doi:10.3390/jfb3010049 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb/ Review Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute Jacob Elmer and Andre F. Palmer * William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 425 Koffolt Laboratories, 140 West 19th Avenue, Columbus, OH 43210, USA; E-Mail: elmer.18@ * Author to whom correspondence should be addressed; E-Mail: palmer.351@; Tel.: +614-292-6033. Received: 21 October 2011; in revised form: 9 December 2011 / Accepted: 24 December 2011 / Published: 6 January 2012 Abstract: Previous generations of hemoglobin (Hb)-based oxygen carriers (HBOCs) have been plagued by key biophysical limitations that result in severe side-effects once transfused in vivo, including protein instability, high heme oxidation rates, and nitric oxide (NO) scavenging. All of these problems emerge after mammalian Hbs are removed from red blood cells (RBCs) and used for HBOC synthesis/formulation. Therefore, extracellular Hbs (erythrocruorins) from organisms which lack RBCs might serve as better HBOCs. This review focuses on the erythrocruorin of Lumbricus terrestris (LtEc), which has been shown to be extremely stable, resistant t