bioinformatics analysis of the frem1 gene—evolutionary development of the il-1r1 co-receptor, tilrr生物信息学分析frem1 gene-evolutionary il-1r1受体的发展,tilrr.pdfVIP

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bioinformatics analysis of the frem1 gene—evolutionary development of the il-1r1 co-receptor, tilrr生物信息学分析frem1 gene-evolutionary il-1r1受体的发展,tilrr.pdf

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bioinformatics analysis of the frem1 gene—evolutionary development of the il-1r1 co-receptor, tilrr生物信息学分析frem1 gene-evolutionary il-1r1受体的发展,tilrr

Biology 2012, 1, 484-494; doi:10.3390/biology1030484 OPEN ACCESS biology ISSN 2079-7737 /journal/biology Article Bioinformatics Analysis of the FREM1 GeneEvolutionary Development of the IL-1R1 Co-Receptor, TILRR Richard C. Hudson, Caroline Gray, Endre Kiss-Toth, Timothy J. A. Chico and Eva E. Qwarnstrom ,* Department of Cardiovascular Sciences, Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK; E-Mails: ricardo.hudson@ (R.C.H.); caroline.gray@sheffield.ac.uk (C.G.); e.kiss-toth@sheffield.ac.uk (E.K.-T.); t.j.chico@sheffield.ac.uk (T.J.A.C.) These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: e.qwarnstrom@sheffield.ac.uk. Received: 23 July 2012; in revised form: 28 August 2012 / Accepted: 3 September 2012 / Published: 25 September 2012 Abstract: The TLRs and IL-1 receptors have evolved to coordinate the innate immune response following pathogen invasion. Receptors and signalling intermediates of these systems are generally characterised by a high level of evolutionary conservation. The recently described IL-1R1 co-receptor TILRR is a transcriptional variant of the FREM1 gene. Here we investigate whether innate co-receptor differences between teleosts and mammals extend to the expression of the TILRR isoform of FREM1 . Bioinformatic and phylogenetic approaches were used to analyse the genome sequenc