有哪些信誉好的足球投注网站znf274 recruits the histone methyltransferase setdb1 to the 3′ ends of znf genesznf274新兵的组蛋白甲基转移酶setdb1 znf 3u2032末端的基因.pdfVIP
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znf274 recruits the histone methyltransferase setdb1 to the 3′ ends of znf genesznf274新兵的组蛋白甲基转移酶setdb1 znf 3u2032末端的基因
ZNF274 Recruits the Histone Methyltransferase SETDB1 to the 39 Ends of ZNF Genes 1 1 1 2 1 Seth Frietze , Henriette O’Geen , Kimberly R. Blahnik , Victor X. Jin , Peggy J. Farnham * 1 Department of Pharmacology and the Genome Center, University of California Davis, Davis, California, United States of America, 2 Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, United States of America Abstract Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factors that drive different cellular lineages. Several histone modifications have been associated with gene silencing, including H3K27me3 and H3K9me3. We have previously shown that genes for the two largest classes of mammalian transcription factors are marked by distinct histone modifications; homeobox genes are marked by H3K27me3 and zinc finger genes are marked by H3K9me3. Several histone methyltransferases (e.g. G9a and SETDB1) may be involved in mediating the H3K9me3 silencing mark. We have used ChIP-chip and ChIP-seq to demonstrate that SETDB1, but not G9a, is associated with regions of the genome enriched for H3K9me3. One current model is that SETDB1 is recruited to specific genomic locations via interaction with the corepressor TRIM28 (KAP1), which is in turn recruited to the genome via interaction with zinc finger transcription factors that contain a Kruppel-associated box (KRAB) domain. However, specific KRAB-ZNFs that recruit TRIM28 (KAP1) and SETDB1 to the genome have not been identified. We now show that ZNF274 (a KRAB-ZNF that conta
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