α1proteinase inhibitor regulates cd4+ lymphocyte levels and is rate limiting in hiv-1 diseaseα1proteinase抑制剂调节cd4 +淋巴细胞水平和速度限制在hiv - 1的疾病.pdfVIP

下载本文档

2
0
约8.85万字
约 10页
2017-09-12 发布于上海
举报
版权申诉

α1proteinase inhibitor regulates cd4+ lymphocyte levels and is rate limiting in hiv-1 diseaseα1proteinase抑制剂调节cd4 +淋巴细胞水平和速度限制在hiv - 1的疾病.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

α1proteinaseinhibitorregulatescd4lymphocytelevelsandisratelimitinginhiv-1diseaseα1proteinase抑制剂调节cd4淋巴细胞水平和速度限制在hiv-1的疾病

a Proteinase Inhibitor Regulates CD4+ Lymphocyte 1 Levels and Is Rate Limiting in HIV-1 Disease 1,2 1,2 3 4 2 Cynthia L. Bristow *, Mariya A. Babayeva , Michelle LaBrunda , Michael P. Mullen , Ronald Winston 1 Weill Cornell Medical College, New York, New York, United States of America, 2 Institute for Human Genetics and Biochemistry, Vesenaz, Switzerland, 3 Holmes Regional Medical Center, Melbourne, Florida, United States of America, 4 Mount Sinai School of Medicine, New York, New York, United States of America Abstract Background: The regulation of adult stem cell migration through human hematopoietic tissue involves the chemokine CXCL12 (SDF-1) and its receptor CXCR4 (CD184). In addition, human leukocyte elastase (HLE) plays a key role. When HLE is located on the cell surface (HLE ), it acts not as a proteinase, but as a receptor for a proteinase inhibitor (a PI, a antitrypsin, CS 1 1 1 SerpinA1). Binding of a PI to HLE forms a motogenic complex. We previously demonstrated that a PI deficiency attends 1 CS 1 HIV-1 disease and that a1PI augmentation produces increased numbers of immunocompetent circulating CD4+ lymphocytes. Herein we investigated the mechanism underlying the a PI deficiency that attends HIV-1 infection.