temporal and spatial regulation of ezrin-radixin-moesin-binding phosphoprotein-50-kda (ebp50) during embryo implantation in mouse uterus时间和空间的监管ezrin-radixin-moesin-binding phosphoprotein-50-kda(ebp50)在小鼠胚胎植入子宫.pdfVIP

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temporal and spatial regulation of ezrin-radixin-moesin-binding phosphoprotein-50-kda (ebp50) during embryo implantation in mouse uterus时间和空间的监管ezrin-radixin-moesin-binding phosphoprotein-50-kda(ebp50)在小鼠胚胎植入子宫.pdf

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temporal and spatial regulation of ezrin-radixin-moesin-binding phosphoprotein-50-kda (ebp50) during embryo implantation in mouse uterus时间和空间的监管ezrin-radixin-moesin-binding phosphoprotein-50-kda(ebp50)在小鼠胚胎植入子宫

Int. J. Mol. Sci. 2012, 13, 16418-16429; doi:10.3390/ijms131216418 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Temporal and Spatial Regulation of Ezrin-Radixin-Moesin-Binding Phosphoprotein-50-kDa (EBP50) during Embryo Implantation in Mouse Uterus Xing Li, Wang-Ming Xu, Tai-Lang Yin, Qing-Hong Zhao, Liang-Yu Peng and Jing Yang * Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; E-Mails: xingli1205@163.com (X.L.); mhlldc@ (W.-M.X.); xj_foreverfriends@126.com (T.-L.Y.); zhaoqinghong_0815@126.com (Q.-H.Z.); tmsygz2005@ (L.-Y.P.) * Author to whom correspondence should be addressed; E-Mail: dryangqing@; Tel.: +86-027-8804-1919; Fax: +86-027-8808-0749. Received: 17 October 2012; in revised form: 15 November 2012 / Accepted: 20 November 2012 / Published: 3 December 2012 Abstract: Embryo implantation is a crucial process for successful pregnancy. To date, the mechanism of embryo implantation remains unclear. Ezrin-radixin-moesin-binding protein-50-kDa (EBP50) is a scaffold protein, which has been shown to play an important role in cancer development. Embryo implantation and cancer follow a similar progression. Thus, in this article, we utilized immunohistochemical staining and western blot analyses to examine the spatiotemporal expression and regulation of EBP50 both in the mouse uterus during embryo implantation as well as in othe