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synthesis of some thienopyrimidine derivatives合成一些thienopyrimidine衍生品
Molecules 2006, 11, 498-513 molecules ISSN 1420-3049 Full Paper Synthesis of Some Thienopyrimidine Derivatives Fatma E. M. El-Baih 1,*, Hanan A. S. Al-Blowy 1 and Hassan M. Al-Hazimi 2 1 Women Students-Medical Studies Sciences Sections, Chemistry Department, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia. Tel.: (+966-1) 477-2245, Fax: (+966-1) 477-2245. 2 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. Tel.: (+966-1) 467-5905, Fax: (+966-1) 467-5992. E-mail: hhazimi@.sa * Author to whom correspondence should be addressed; E-mail: zahraa205@ Received: 12 June 2006; in revised form: 28 June 2006 / Accepted: 2 July 2006 / Published: 5 July 2006 Abstract: Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2-amino-3-cyano-4,5-disubstituted thiophenes via reactions with different reagents. Keywords: Thioxothienopyrimidinones, alkyl- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines, thienopyrimidinediones, thienotriazolo- pyrimidinones. Introduction Many thienopyrimidines are found to exhibit a variety of biological activities, including antiinflammatory [1,2], antimicrobial [3] and analgesic [4] properties, inhibition of cancer cell proliferation [5], antagonism of α1 adrenoceptors [6] and preventi
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