有哪些信誉好的足球投注网站t-cell immune responses against env from crf12_bf and subtype b hiv-1 show high clade-specificity that can be overridden by multiclade immunizationst细胞免疫反应对env crf12_bf和hiv - 1 b亚型可以覆盖显示高clade-specificity multiclade免疫接种.pdfVIP
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t-cell immune responses against env from crf12_bf and subtype b hiv-1 show high clade-specificity that can be overridden by multiclade immunizationst细胞免疫反应对env crf12_bf和hiv - 1 b亚型可以覆盖显示高clade-specificity multiclade免疫接种
T-Cell Immune Responses Against Env from CRF12_BF and Subtype B HIV-1 Show High Clade-Specificity that Can Be Overridden by Multiclade Immunizations ´ 1 ´ 1 ´ 1 1 1 Daniela C. Monaco , Ana M. Rodrıguez , Marıa F. Pascutti , Mauricio Carobene , Juliana Falivene , ´ 1 1 1 ´ ´ 2 2 Alejandro Gomez , Cynthia Maeto , Gabriela Turk , Jose L. Najera , Mariano Esteban , M. Magdalena Gherardi1* ´ 1 Centro Nacional de Referencia para el SIDA, Universidad de Buenos Aires, Buenos Aires, Argentina, 2 Departamento de Biologıa Molecular y Celular, Centro Nacional de ´ ´ Biotecnologıa, CSIC, Campus Universidad Autonoma, Madrid, Spain Abstract Background: The extreme genetic diversity of the human immunodeficiency virus type 1 (HIV-1) poses a daunting challenge to the generation of an effective AIDS vaccine. In Argentina, the epidemic is characterized by the high prevalence of infections caused by subtype B and BF variants. The aim of this study was to characterize in mice the immunogenic and antigenic properties of the Env protein from CRF12_BF in comparison with clade B, employing prime-boost schemes with the combination of recombinant DNA and vaccinia virus (VV) vectors. Methodology/Principal Findings: As determined by ELISPOT from splenocytes of animals immunized with either EnvBF or EnvB antigens, the majority of the cellular responses
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