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Sensors 2012, 12, 10136-10147; doi:10.3390/s120810136 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Communication Synthesis of Bioactive Microcapsules Using a Microfluidic Device Byeong Il Kim 1,2,†, Soon Woo Jeong 1,2,†, Kyoung G. Lee 1, Tae Jung Park 3, Jung Youn Park 4, Jae Jun Song 5, Seok Jae Lee 1,* and Chang-Soo Lee 2,* 1 Center for Nanobio Integration Convergence Engineering (NICE), National Nanofab Center, 291 Daehak-ro, Yuseong-gu, Daejeon 305-806, Korea; E-Mails: kbiset@nnfc.re.kr (B.I.K.); swjeong@nnfc.re.kr (S.W.J.); kglee@nnfc.re.kr (K.G.L.) 2 Department of Chemical Engineering, Chungnam National University, 220 Gung-Dong, Yuseong-gu, Daejeon 305-764, Korea 3 Department of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756, Korea; E-Mail: tjpark@cau.ac.kr 4 Biotechnology Research Division, National Fisheries Research Development Institute (NFRDI), 408-1 Sirang-ri, Gijang, Busan 619-705, Korea; E-Mail: jypark@nfrdi.go.kr 5 Microbe-based Fusion Technology Research Center, KRIBB, 1404 Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea; E-Mail: jjsong@kribb.re.kr † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: sjlee@nnfc.re.kr (S.J.L.); rhadum@cnu.ac.kr (C.-S.L.); Tel.: +82-42-879-9722 (S.J.L.); Fax: +82-42-879-9609 (S.J.L.); Tel.: +82-42-821-5896 (C.-S.L.); +82-42-822-8995 (C.-S.L.). Received: 8 June 2012; in revised form: 4 July 2012 / Accepted: 18 July 2012 / Published: 26 July 2012 Abstract: Bioactive microcapsules containing Bacillus th