t-cell contact-dependent regulation of cc and cxc chemokine production in monocytes through differential involvement of nfκb implications for rheumatoid arthritist细胞contact-dependent监管cc和科学家在单核细胞趋化因子生产通过微分的参与nfκb对类风湿性关节炎的影响.pdfVIP

t-cell contact-dependent regulation of cc and cxc chemokine production in monocytes through differential involvement of nfκb implications for rheumatoid arthritist细胞contact-dependent监管cc和科学家在单核细胞趋化因子生产通过微分的参与nfκb对类风湿性关节炎的影响.pdf

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t-cell contact-dependent regulation of cc and cxc chemokine production in monocytes through differential involvement of nfκb implications for rheumatoid arthritist细胞contact-dependent监管cc和科学家在单核细胞趋化因子生产通过微分的参与nfκb对类风湿性关节炎的影响

Available online /content/8/6/R168 Vol 8 No 6 Open Access Research article T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis 1 2 1 1 Jonathan T Beech *, Evangelos Andreakos *, Cathleen J Ciesielski , Patricia Green , Brian MJ Foxwell1 and Fionula M Brennan1 1Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK 2Foundation for Biomedical Research of the Academy of Athens, Center for Immunology and Transplantations, 4 Soranou tou Ephessiou, 11527 Athens, Greece * Contributed equally Corresponding author: Jonathan T Beech, j.beech@ic.ac.uk Received: 7 Jun 2006 Revisions requested: 28 Jun 2006 Revisions received: 28 Sep 2006 Accepted: 13 Nov 2006 Published: 13 Nov 2006 Arthritis Research Therapy 2006, 8:R168 (doi:10.1186/ar2077) This article is online at: /content/8/6/R168 © 2006 Beech et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We and others have reported that rheumatoid arthritis (RA) by T cells activated with a cytokine cocktail containing IL-2, IL-6 synovial T cells can activate human monocytes/macrophages in and TNFα, but not T cells activated by anti-CD3 cross-linking a contact-dependent manner to induce the expression

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