tea polyphenols and their roles in cancer prevention and chemotherapy茶多酚和他们的角色在癌症预防和化疗.pdfVIP

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tea polyphenols and their roles in cancer prevention and chemotherapy茶多酚和他们的角色在癌症预防和化疗.pdf

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tea polyphenols and their roles in cancer prevention and chemotherapy茶多酚和他们的角色在癌症预防和化疗

Int. J. Mol. Sci. 2008, 9, 1196-1206; DOI: 10.3390/ijms9071196 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /ijms Review Tea Polyphenols and Their Roles in Cancer Prevention and Chemotherapy Di Chen * and Q. Ping Dou The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA E-Mails: chend@ (Di Chen); doup@ (Q. Ping Dou) *Author to whom correspondence should be addressed; Tel. 01-313-576-8264; Fax: 01-313-576-8928 Received: 8 May 2008; in revised form: 26 June 2008 / Accepted: 27 June 2008 / Published: 12 July 2008 Abstract: Many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. The more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these “natural gifts” for the prevention and treatment of human cancer. Furthermore, better understanding of their structure-activity relationships will guide synthesis of analog compounds with improved bio-availability, stability, potency and specificity