synthesis of n-acetyl-n-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-4-yl)-acetamide合成n-acetyl-n -(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02 6]dec-4-yl)乙酰胺.pdfVIP

M533 Synthesis of NacetylN(3,5dioxo10oxa4azatricyclo[5.2 Molbank 2007, M533 /molbank/ Synthesis of acetyl(3,5dioxo10oxa4aza tricyclo[2, ]dec4yl)acetamide 1* 1 2 2 Marta Struga , Jerzy Kossakowki , Barbara Mirosław , Anna E. Kozioł 1 The Medical University, Department of Medical Chemistry, 3 Oczki Str., 02007 Warsaw, Poland; Tel/Fax: (+4822)6280679 2 Faculty of Chemistry, Maria CurieSkłodowska University, 20031 Lublin, Poland * Author to whom correspondence should be addressed. Email: strugam@wp.pl Received: 27 September 2006 / Accepted: 16 January 2007 / Published: 31 May 2007 Keywords: 4amino10oxa4azatricyclo[2,6]dec8ene3,5dione, acylation Various imide derivatives of 10Oxa4azatricyclo[2,6]decane3,5dione have been reported and shown to exhibit a wide spectrum of biological activities including antitumor properties [1]. 4Amino10oxa4azatricyclo[2,6]dec8ene3,5dione (1) was used as a starting material. This compound was obtained in DielsAlder reaction of furan and furan2,5dione [2] and next treated with hydrazine (80% aqueous solution) [3]. Compound 2 was obtained in acylation reaction of compound 1. The reduction of compound 2 occurred during the acylation. 2,6 acetyl(3,5dioxo10oxa4azatricyclo[ ]dec4yl)acetamide (2). 0.01 Mole of the compoun